Koch and His Postulates

Koch ’ s Postulates — Then and Now

T his story begins in the early 1880s. The germ theory of disease was fairly well established, although some experts continued to challenge it. For example, Theodor Billroth (1829– 1894) of Vienna, often called the founding father of abdominal surgery, did not immediately accept the germ theory, but later embraced the concept and became very successful in many pioneering surgeries. Another crit...

Causation and Disease: The Henle-Koch Postulates Revisited 1

The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments. The changing guidelines developed for viral diseases, for viruses in relation to cancer and to chronic central nervous system infection, and for causative agents in chronic diseases are discussed chronologically. A set of guidelines for both acute infectious and chronic ...

Toward a more systematic understanding of bacterial virulence factors and establishing Koch postulates in silico

Human health is threatened by various infectious bacterial pathogens but is also supported by many commensal bacteria particularly in the intestinal tract. However, many of the bacterial pathogens and commensal bacteria are taxonomically indistinguishable, with pathogenic and commensal bacteria existing in the same genus and even species. A typical example is Escherichia coli, which is commonly...

Computability of Koch Curve and Koch Island

Koch curve is known as a typical self-similar set on Euclidean plane. Koch island is a closed set surrounded by three copies of Koch curve. We investigate them from the viewpoint of computability. In this paper, we define computability of a curve and that of a closed set as an application of classical computable analisys to Euclidean spaces and show that Koch curve is a computable curve and bot...

Behavior postulates and corollaries--1949.